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Induction of T
ISCK03 945526
Multiscale profiling of protease activity in cancer PMID 36192379
Atp2a2
TOX
Di
Lopinavir impurity 19 (Lopinavir impurity T)
MUC15 Human Pre
TMR
Role of lysophosphatidylcholine (LPC) in atherosclerosis PMID 18220755
Radezolid Is More Effective Than Linezolid Against Planktonic Cells and Inhibits Enterococcus faecalis Biofilm Formation PMID 32117185
C6
Activation of p62
Aluminum chloride induced neurofibrillary changes in the developing rabbit a chronic animal model PMID 7192069
H
Design, synthesis and biological evaluation of a new series of thiazolyl
7
Cathepsin C
ASP2535 374886
Two types of seizures in homocysteine thiolactone
PI3kδ inhibitor 1
Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF
p38
Snrpa
ADAM23 Human Pre
MAO
Antibiotic Conjugates with an Artificial MECAM
Gpr101
Indispensable role of mitochondria in maintaining the therapeutic potential of curcumin in acute kidney injury PMID 34532973
Hemin enhances radiosensitivity of lung cancer cells through ferroptosis PMID 34826424
N2
LIM 同源框 6（LHX6）基因
Ribociclib impurity 3 (Ribociclib impurity C)
Rational design of phosphoinositide 3
5
Screening of natural product libraries in MCF7 cell line reveals the pro
氟苯
A Novel Pharmacological Approach to Enhance the Integrity and Accelerate Restitution of the Intestinal Epithelial Barrier PMID 32266946
BCAS2
NFLINETAR 2007127
transitions
DSM502 2426616
Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1 PMID 22658960
Neonatal Tissue
TNFSF13B
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ( Danshen ) PMID 23286284
Antagonistic action of imidazolineoxyl N
5H
Rationally designed haptens for highly sensitive monoclonal antibody
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo PMID 31827706
Topiroxostat 577778
Lrp1b
HBV capsid assembly modulators differentially modulate the assembly of wild
Altenusin 31186
Nicaraven 79455
Single therapeutic and supratherapeutic doses of sacubitril/valsartan (LCZ696) do not affect cardiac repolarization PMID 27083930
KLRG1 impairs regulatory T
A PEG
IGS
Functional validation of Capsicum frutescens aminotransferase gene involved in vanillylamine biosynthesis using Agrobacterium mediated genetic transformation studies in Nicotiana tabacum and Capsicum frutescens calli cultures PMID 22921003
CD300e 蛋白, Mouse (HEK293, hFc)
Synthesis and biological evaluation of aryloxazole derivatives as antimitotic and vascular
(E)
(S)
Il16 Rat Pre
TAK1/MAP4K2 inhibitor 1 1315330
trans
Bruceine A inhibited breast cancer proliferation and metastasis by inducing autophagy via targeting PI3K
Claudin
Macrophylline 27841
Selective Inhibitors of G2019S
The precise chemical
C1qb
Sertaconazole
Fibroblast growth factor receptor 1/Klothoβ agonist BFKB8488A improves lipids and liver health markers in patients with diabetes or NAFLD A phase 1b randomized trial PMID 35993161
α
骨形态发生蛋白受体 1B 型（BMPR1B）基因
Amylin induces hypoglycemia in mice PMID 23460444
Metallothionein 2 activation by pravastatin reinforces epithelial integrity and ameliorates radiation
Blockade of TIM
Mniopetal C 158761
Ac
KIRA6 1589527
Conditional Knockout of IL
WIN 54954 107355
MIF regulates T helper 17 cell differentiation by activating the p38 MAPK signaling pathway to drive the pathogenesis of EAP PMID 40440956
Hydrogel delivering antifibrotic agent and nano
XL388 1251156
Anisopirol 857
TD
Crassicauline A 79592
EZH1/2 plays critical roles in oocyte meiosis prophase I in mice PMID 39511641
Further knowledge on barley (Hordeum vulgare L.) leaves O
HA14
Flufenamic acid as an ion channel modulator PMID 23356979
D
Palmitic acid
Flumethrin (FCR 2769)
Dctn1 Mouse Pre
CSV0C018875 442150
Proteome
Proteolysis
Veledimex (S enantiomer) 1093131
Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti
15(R)
Enniatin A1
PLLA4000
N,N
Effect of O
Git2
IL
丝裂原活化蛋白激酶激酶激酶 7（MAP3K7）基因
Boc
2,4
Cytotoxic triterpenoids from the stem bark of Aglaia angustifolia PMID 32536210
Perillaldehyde Ameliorates Aspergillus fumigatus Keratitis by Activating the Nrf2/HO
Ensulizole 27503
Mesalamine
Protective effect of docosahexaenoic acid on lipotoxicity
UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination PMID 32807901
Farrerol 4& 039;,7
BBO
PBX
Nampt
Diet
Fasinumab 1190239
Multivalent Small
Asymmetric distribution of hypoxia
Malvidin
Atractylodin modulates ASAH3L to improve galactose metabolism and inflammation to alleviate acute lung injury PMID 39351199
Lysosphingolipid Quantitation in Plasma and Dried
Fenirofibrate impurity 6 (Fenirofibrate impurity D)
MOFs
NDC80 Human Pre
CRS3123 1013915
Inhibitory effects of isocryptotanshinone on gastric cancer PMID 29915371
Ternatumoside II 1473419
ADAMTS1 and HSPG2 mRNA levels in cumulus cells are related to human oocyte quality and controlled ovarian hyperstimulation outcomes PMID 31974739
Vcl Mouse Pre
Natural Product Kongensin A is a Non
Alpha4
High
TIM
DNA Topoisomerase Inhibitory Activity of Constituents from the Flowers of Inula japonica PMID 26936053
Acetate utilization promotes hormone therapy resistance in prostate cancer through neuroendocrine differentiation PMID 39395327
Amiloride, a urokinase
Reactivation of latent HIV
The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A PMID 14996846
Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo PMID 12110615
Front
β
GP1 precursor 1423134
2
The alpha
MCE
Bruceine A induces cell growth inhibition and apoptosis through PFKFB4/GSK3β signaling in pancreatic cancer PMID 33992797
Discovery and in Vivo Evaluation of Macrocyclic Mcl
Nalbuphine PMID 30000297
[Quinones and related compounds in higher plants. VII. Supplementary studies on the constituents of the wood of Catalpa ovata (author's transl)] PMID 544777
BDE
Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403 PMID 11181422
The binding of 1,N6
S
Rezuforimod 1431754
Naringinases occurrence, characteristics, and applications PMID 21544655
FGF19 Human Pre
Elacridar
Rotigotine 99755
Cytotoxicity, Colour Stability and Dimensional Accuracy of 3D Printing Resin with Three Different Photoinitiators PMID 35267799
Blocking AURKA with MK
Synthesis and Structure
BRD4L cooperates with MYC to block local tumor invasion via suppression of S100A10 PMID 38604343
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment PMID 12109914
Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR
Dipyridamole inhibition of adenosine metabolism in human blood PMID 6628545
Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering PMID 27578247
Rhod Mouse Pre
Role of CYP2D6 in the stereoselective disposition of venlafaxine in humans PMID 12544511
Fgf14 Mouse Pre
Loxl3 Rat Pre
Ropinirole
Unveiling the Impact of BMP9 in Liver Diseases Insights into Pathogenesis and Therapeutic Potential PMID 39199400
Regulation of heme oxygenase
Rp
8
Suppressive effects of 3
Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor
CP
DOTA
Isbufylline 90162
Endothelial CDS2 deficiency causes VEGFA
6
Cytokines and Chemokines in SARS
Redirecting the revolution new developments in drug development for psychiatry PMID 31545131
SERTAD2 Human Pre
(E)
Establishment of Tripterygium wilfordii Hook. f. Hairy root culture and optimization of its culture conditions for the production of triptolide and wilforine PMID 24651642
MiR
Glycochenodeoxycholic Acid Does Not Increase Transforming Growth Factor
Exosomal miR
Pancreatic β cell interleukin
Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X
Antihypertensive effects of CS
Evodiamine inhibits programmed cell death ligand 1 expression via the PI3K/AKT signaling pathway to regulate antitumor immunity in melanoma PMID 39994441
1,2
Salmeterol impurity 7 (Salmeterol impurity H)
Cordyceps Sinensis Reduces Inflammation and Protects BEAS
MCE
Iguratimod decreases bleomycin
The discovery of benzoxazine sulfonamide inhibitors of NaV1.7 Tools that bridge efficacy and target engagement PMID 28629594
Linderene acetate
Hydroxyisogermafurenolide
Apiopaeonoside (丹皮酚新苷)
Validated RP
tBu
LDHA deficiency inhibits trophoblast proliferation via the PI3K/AKT/FOXO1/CyclinD1 signaling pathway in unexplained recurrent spontaneous abortion PMID 36583693
Single cell characterization of B
SR59230A hydrochloride 1135278
MrgprX2 antagonist
Discovery of 3
CarnoSyn
Effects of GM1 ganglioside and its derivatives on ETI
Dopamine D3 receptor antagonist
Adiantulupanone 51511
NL13, a novel curcumin analogue and polo like kinase 4 inhibitor, induces cell cycle arrest and apoptosis in prostate cancer models PMID 39142876
Erbin alleviates sepsis
乙酸钠
(E)
Long non
Mechanism of Siponimod Anti
C5
Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms PMID 24705905
自然杀伤细胞
TTK/PLK1
GIGYF1 Human Pre
Capillary electrophoresis of baclofen with argon
A
Alkyne Cholesterol 1631985
U
(±)
Effect of chronic administration of forskolin on glycemia and oxidative stress in rats with and without experimental diabetes PMID 24688307
Multifaceted roles of CCL20 (C
KIFAP3 Human Pre
CRBN ligand
Identification and regulation of a novel leptin receptor
Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index 1 PMID 26692561
Conditional expression of fibroblast growth factor
Sub
Phytochemical Analysis and Biological Activities of the Ethanolic Extract of Daphne sericea Vahl Flowering Aerial Parts Collected in Central Italy PMID 33802543
RG3039 hydrochloride
GLYCTK Human Pre
The effects of chronic trimipramine treatment on biogenic amine metabolism and on dopamine D2, 5
Arhgef6
MCE
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2
CSNK2A2 promotes Hepatocellular carcinoma progression through activation of NF
FGF14 Human Pre
Pharmacological properties of the gastric H(+)/K(+) ATPase inhibitor, AU
MLANA Human Pre
Design, Synthesis, and Biological Evaluation of a Series of Novel LFA
Development of pyrimidine
Angiocidin inhibitory peptides decrease tumor burden in a murine colon cancer model PMID 17719063
Simultaneous Determination of Formononetin, Calycosin and Rhamnocitrin from Astragalus Complanatus by UHPLC
Hspb2
An in vitro screening technique for DNA polymerases that can incorporate modified nucleotides. Pseudo
Sodium α
Tnfrsf12a Mouse Pre
THY1
Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance PMID 35817773
PIM kinase inhibitors downregulate STAT3(Tyr705) phosphorylation PMID 20667852
Fdx1
Identification and field evaluation of the sex pheromone of Synanthedon bicingulata (Staudinger) PMID 21399964
Shc3
UNBS3157 868962
Polyamine metabolism controls B
N1
CALCB 蛋白, Human (HEK293, mFc)
Glyphosate
Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation PMID 22389503
BSCL2 Human Pre
Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb
Miltirone, a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhiza PMID 1652718
Inhibition of Cdk5 Promotes β
α
RNA tailing machinery drives amyloidogenic phase transition PMID 38805292
Chemical probes that competitively and selectively inhibit Stat3 activation PMID 19274102
Cdhr3 Rat Pre
PTI
In vitro antitrypanosomal activities of quassinoid compounds from the fruits of a medicinal plant, Brucea javanica PMID 18986767
PAF antagonistic activity of some thieno[3,2
Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1
Effects of LRRK2 Inhibitors in Nonhuman Primates PMID 37916535
Small molecule/ML327 mediated transcriptional de
Evaluation of the influence of radiation
Larazotide acetate regulates epithelial tight junctions in vitro and in vivo PMID 22401908
PROTAC CDK2
HY
Lead optimization of a CHI3L1 inhibitor for Glioblastoma Enhanced target engagement, pharmacokinetics, and efficacy in 3D spheroid models PMID 40602224
The Application of Microsampling Disks in Circular Dichroism Spectroscopy for Peptide and Nucleic Acid Drugs PMID 38987173
Tnfsf14
Nup88 Mouse Pre
线粒体核糖体蛋白 S10（MRPS10）基因
Toll 样受体 9（Tlr9）基因
Z
Effects of proton pump inhibitors on reversing multidrug resistance via downregulating V
Say no to DMSO dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes PMID 24812268
2
Cyclo(Tyr
ROS
D
coordinating
Sulforaphene inhibits esophageal cancer progression via suppressing SCD and CDH3 expression, and activating the GADD45B
Vanillylamine
Captan
PKD1
Hepatitis B virus core protein promotes the expression of neuraminidase 1 to facilitate hepatocarcinogenesis PMID 32686743
NCGC00262650 344359
Rufinamide
A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV
Targeting Glycogen Synthase Kinase 3 Beta Regulates CD47 Expression After Myocardial Infarction in Rats via the NF
SMCC
Lacto
STL 127705
Synthesis and anticancer activities of 5,6,7
DNA
5′
STL
PF02413873
The RNA
Hydroxy
PF 02413873
Dietary limonin ameliorates heart failure with preserved ejection fraction by targeting ferroptosis via modulation of the Nrf2/SLC7A11/GPX4 axis an integrated transcriptomics and metabolomics analysis PMID 40230319
Mechanistic study of METTL3 inducing ferroptosis to promote cervical cancer progression through mediating m6A modification of COTE
Irisin alleviates renal injury caused by sepsis via the NF
CRBN ligand
Sulfo
Network pharmacology integrated with experimental validation reveals the mechanism of Xanthii Fructus against allergic rhinitis via JAK2/STAT3/HIF
Analysis of key genes reveal lysine demethylase 5B promotes prostate cancer progression PMID 32863895
Gb3(d18 1/16 0)
Separase a universal trigger for sister chromatid disjunction but not chromosome cycle progression PMID 16533945
Antioxidative activity of (
6
Angiostatin generation by cathepsin D secreted by human prostate carcinoma cells PMID 10986284
MicroRNA
Cell cycle heterogeneity directs spontaneous 2C state entry and exit in mouse embryonic stem cells PMID 34624246
Mindeudesivir 2647442
SBI
CSPG5 Human Pre
CRBN ligand
Tubulin inhibitor 33 2944462
半胱天冬酶 12（Casp12）基因
Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis PMID 34757590
Ribavirin 5'
Transcription Factor ETV4 Activates AURKA to Promote PD
JAK1
Garcinone C 76996
Carazolol a potent, selective beta 3
Down
Bis
Myristoyl
Alvimopan dihydrate 170098
[1,1'
Flaccidoside II 140694
TRK
Acetic acid suppresses the increase in disaccharidase activity that occurs during culture of caco
trans
DABCYL
Melatonin Ameliorates Circadian Disruption
FGFR1 governs iron homeostasis via regulating intracellular protein degradation pathways of IRP2 in prostate cancer cells PMID 39154074
CAU
Oleanolic acid derivative 2 211516
Oroxylin A ameliorates ultraviolet radiation
5
Non
Geniposide alleviates VEGF
1,2
Curcumin alleviates rheumatoid arthritis
miR
Caspase
Chrysoeriol ameliorates TPA
MiR
CAIX
TSLP 蛋白, Human (R127A, R130A, HEK293, His)
Suppression of FOXO3 by BMP signaling contribute to the different primordial germ cell proliferation between layers and broilers† PMID 39987556
Function of hesperidin alleviating inflammation and oxidative stress responses in COPD mice might be related to SIRT1/PGC
LOC102120479
Hydroaurantiogliocladin 776
Acetylation of PGK1 at lysine 323 promotes glycolysis, cell proliferation, and metastasis in luminal A breast cancer cells PMID 39192221
Boc
VEGFR
A carbocyanine dye, DiOC6(3), acts as a mitochondrial probe in human neutrophils PMID 7181903
Circadian disruption impairs glucose homeostasis in male but not in female mice and is dependent on gonadal sex hormones PMID 36645117
Vesicle trafficking plays a novel role in erythroblast enucleation PMID 20644112
PSB
Lachnospiraceae
Inhibition of O
2
DC271 198696
Protocol for stromal vascular fraction isolation from inguinal subcutaneous white adipose tissue and beige adipocyte differentiation PMID 41014562
Compounds from Sichuan and Melegueta peppers activate, covalently and non
Rapid and high
2,2′,4,4′,5
Synthesis and anticancer activity of novel 4
Design, synthesis and bioactivity evaluation of a series of quinazolinone derivatives as potent PI3Kγ antagonist PMID 37011446
Synthesis and structure
EGR
SB
BTA
4
Basidalin 82501
GPR88 agonist 2 2821859
TIM
MC
Constituents of Salvia microphylla PMID 16753912
CRBN ligand
Sirtuin modulator 6 476633
Integrin αIIbβ3 outside
HNMPA 132541
Comparison of Intra
PRMT5 ligand 3 1616397
Retapamulin 224452
Timp3 Rat Pre
Veratric acid
ZM 447439 inhibition of aurora kinase induces Hep2 cancer cell apoptosis in three
Oct3/4
MAO
Synthesis and anticancer activity of some 5
Garcinone C suppresses colon tumorigenesis through the Gli1
SP1
The combined treatment of NAD+ and atorvastatin ameliorates the development of experimental autoimmune encephalomyelitis in C57BL/6 mice PMID 33176238
Isomaltotetraose (异麦芽四糖)
Bisphenol
Acetyl xylan esterase, Cellvibrio japonicus
Acetyl xylan esterase, Clostridium thermocellum
15
Nitro
Mlana
Design, synthesis, and evaluation of PD
JNK
Lysylcysteine TFA (L
Curcumin combined with arsenic trioxide enhances autophagy and immune surveillance to inhibit immune escape in acute myeloid leukemia PMID 40440957
(±)
GALA
ML327 (Standard)
LY580276
ZMC2
Carbonic anhydrase, E. coli
Pharmacological properties of 5
(−)
CATR
α2
α
β
ML
Severibuxine 219998
Identification of chemical scaffolds for targeting ubiquitin
CSNK1G1 蛋白, Human (Active, sf9, GST)
Tricetinidin chloride 65618
Discovery of novel dual inhibitors of the wild
Exenatide inhibits necrosis by enhancing angiogenesis and ameliorating ischemia/reperfusion injury in a random skin flap rat model PMID 33214096
Plumbagin improves the efficacy of androgen deprivation therapy in prostate cancer A pre
Pimozide
Fengreqing Oral Liquid Exerts Anti
Molecular Tweezers
A small
MCE
S
FGFR3
CBP Bromodomain Inhibition Rescues Mice From Lethal Sepsis Through Blocking HMGB1
FABP9 蛋白, Human
MED12 抗体 (YA6652)（MED12 Antibody (YA6652)）
Design, synthesis, in silico pharmacokinetics prediction and biological evaluation of 1,4
CGP
Endonuclease VIII 118390
Hagh Rat Pre
Blood
SAINT
(5E,9E,13E)
1,2
12
HA/Hemagglutinin 蛋白, H1N1 (AEI30056, HEK293, His)
MCE
DL5050 2259710
含锌指 CCCH 型，抗病毒 1（ZC3HAV1）基因
15 0 Lyso PC 108273
Isoorientin
Methyl 2,3
KRAS G12D inhibitor 13
Cbz
Enantioselective effects of (+)
Adalimumab 331731
A novel anti
熔解温度
Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S
Effects of ONO
Bilastine
MCE
AH
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