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钙粘蛋白 13（CDH13）基因
Metformin ameliorates mitochondrial damage induced by C9orf72 poly(GR) via upregulating AKT phosphorylation PMID 38229533
Molecular structure of the halogenated anti
Effective ciprofloxacin cationic antibacterial agent against persister bacteria with low hemolytic toxicity PMID 38354522
(R)
CRBN ligand
TG 100572 hydrochloride (Standard)
FXa
Simazine
Apelin
Delmadinone acetate 13698
CRBN ligand
AU
Phosphodiesterase type 5 inhibitor tadalafil reduces prostatic fibrosis via MiR
Ro 32
Combined bone marrow stromal cells and oxiracetam treatments ameliorates acute cerebral ischemia/reperfusion injury through TRPC6 PMID 31236585
Acetic acid
IGF
Apoptosis inducer 34 582314
Glyceollin II 67314
SHANK2
CD73/5'
Cyclo(Ile
Specific BK Channel Activator NS11021 Protects Rat Renal Proximal Tubular Cells from Cold Storage
S100A9
Functional characterization of a putative lipopolysaccharide
Induction of insulin resistance in female mice due to prolonged phenanthrene exposure unveiling the low
Rimigorsen 1196915
Mergetpa 77102
MCE
Catharanthine 2468
Animal
Boosting the efficacy of anti
BR102910 2505339
Integration of transcriptomics, metabolomics, and lipidomics reveals the mechanisms of doxorubicin
NCOA5 induces sorafenib resistance in hepatocellular carcinoma by inhibiting ferroptosis PMID 40316542
Post
Rolapitant hydrochloride 858102
AFP464 free base 468719
Antinociception by intrathecal midazolam involves endogenous neurotransmitters acting at spinal cord delta opioid receptors PMID 9014630
13(S)
BAI1 hydrochloride 329349
o
MAT2A inhibitor 5 2957874
1(R),2(S)
Isopropyl β
Octadeca
NG 52 212779
PPL
Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage PMID 32450897
RNA splicing modulator 3 2726461
CKI
Ube2w Rat Pre
20(S)
CP61 1631984
Liquid chromatography
ADX47273 [S
hsa
NBC19 2068818
Flurbiprofen sodium 56767
Targeting C3b/C4b and VEGF with a bispecific fusion protein optimized for neovascular age
5
DiBoc
含硫氧还蛋白结构域 17（TXNDC17）基因
HA/Hemagglutinin 蛋白, H1N1 (ABD77675, HEK293, His)
(2
Dual inhibition of oxidative phosphorylation and glycolysis exerts a synergistic antitumor effect on colorectal and gastric cancer by creating energy depletion and preventing metabolic switch PMID 39666615
LTD4 antagonist 3 (FK011 hydrochloride)
Octaethylene glycol monododecyl ether 3055
D
A Highly Selective Fluorescent Probe for Detection of Hydrogen Sulfide in Living Systems In Vitro and in Vivo Applications PMID 28474839
UCUF
Periplocin promotes wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K
FBP2
MSX3 261717
2
Trovafloxacin mesylate 147059
Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering PMID 26546219
Inhibition of intermittent calcium
Poloxime 17302
BODIPY FL C5 217075
Bisphenol A β
GW632046X
(Asp28)
A COX
泛素折叠修饰符 1（UFM1）基因
Catabolism of extracellular glutathione supplies cysteine to support tumours PMID 41851454
Igfbp2
TPO/Thrombopoietin 蛋白, Human (HEK293, C/N
Potassium dihydrogen phosphate promotes the proliferation and differentiation of human periodontal ligament stem cells via nuclear factor kappa B pathway PMID 31487508
MCE
微管蛋白 2B IIb 类（TUBB2B）基因
Pomalidomide
Chemokine receptor CXCR3 agonist prevents human T
Subchronic oral toxicity assessment of N
Targeting Myeloid
P
Demethyleneberberine, a natural mitochondria
Systemic effects produced by echothiophate iodide in treatment of glaucoma PMID 13955705
NH2
Hemodynamic and electrocardiographic consequences of high
MCE
Discovery of a Potent, Selective, and Cell
Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma PMID 36070144
Dropropizine 17692
Histone β
Comprehensive characterization of the Published Kinase Inhibitor Set PMID 26501955
Tfe3 Rat Pre
CRBN ligand
FCN
NB
Irisin reverses insulin resistance in C2C12 cells via the p38
Dopamine β
Saikosaponin E 64340
AalphaC 26148
Inhibition of NETs prevents doxorubicin
Ursodeoxycholic acid
Antimicrobial compounds from an FDA
Sonidegib diphosphate 1218778
1
BPC 157 acetate 1628202
Suppressed macrophage response to quorum
Array
Inhalable polysorbates stabilized nintedanib nanocrystals to facilitate pulmonary nebulization and alveolar macrophage evasion PMID 39471574
Anti
AICAr to SAICAr ratio can serve as additional marker of AICAr use PMID 36342242
Verzistobart 2649466
Atrazine
dBET1 1799711
iJAZ
Acid orange 74
O
Characterization of selective Calcium
Sildenafil
Two
DBPR114
肿瘤蛋白 p53 调节凋亡诱导蛋白 1（TP53AIP1）基因
Whole structure
Identification and chemical synthesis of a host cell receptor binding site on hepatitis B virus PMID 3015414
α
HIDA
DBPR
The benzenesulfoamide T0901317 [N
Antileishmanial activity of three saponins isolated from ivy, alpha
Antimicrobial peptide A20L in vitro and in vivo antibacterial and antibiofilm activity against carbapenem
Barbituric Acid Derivatives as Covalent Inhibitors of Leishmania braziliensis Dihydroorotate Dehydrogenase PMID 40658390
Polystyrene sulfonic acid (30% in water) 28210
Triptobenzene H 146900
Biased allosteric agonism and modulation of metabotropic glutamate receptor 5 Implications for optimizing preclinical neuroscience drug discovery PMID 27392634
DL
Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ
K(+)
Melperone hydrochloride 1622
Synthesis of hybrid phosphorated indenoquinolines and biological evaluation as topoisomerase I inhibitors and antiproliferative agents PMID 34952177
RESTORE
Discovery of a potent PARP1 PROTAC as a chemosensitizer for the treatment of colorectal cancer PMID 39602992
Novel PD
Lgals4
Periplocin targets LRP4 to regulate metabolic homeostasis and anti
RacGAP1 ameliorates acute kidney injury by promoting proliferation and suppressing apoptosis of renal tubular cells PMID 32423815
Three new xanthones from the resin of Garcinia hanburyi PMID 23670620
Primordazine NC
Bupropion impurity 6 119802
Synthesis, anticancer activity and DNA
a
DA
SR 12343
3’
BRD6688 1404562
Metronidazole acid acyl sulfonamide a novel class of anticancer agents and potential EGFR tyrosine kinase inhibitors PMID 21920766
Iodoacetyl
Prochlorperazine sulfoxide
Antibacterial phenolic components from Eriocaulon buergerianum PMID 18191163
LIFR 蛋白, Mouse (HEK293, His)
The prohibitin
Irf9
Tribuloside Mechanisms and Efficacy in Treating Acute Lung Injury Revealed by Network Pharmacology and Experimental Validation PMID 38725454
Amplified therapeutic targets in high
MrgprX2 antagonist
High
Decoding the Functional Evolution of an Intramembrane Protease Superfamily by Statistical Coupling Analysis PMID 32795403
Ketoprofen
Stx1b
RNF216 Human Pre
Betulinic acid palmitate
A humanized monoclonal antibody targeting the β7 integrin selectively blocks intestinal homing of T lymphocytes PMID 21232034
BI1002494 1319738
1
K
红莲蛇菰提取物 (Thonningia sanguinea Vahl)
GC
Dickkopf1 fuels inflammatory cytokine responses PMID 36539532
Inhibition of the type I interferon receptor pathway protects against muscle weakness induced by dermatomyositis serum PMID 41850941
CD302
MiR
4
4
Usp15 Rat Pre
(25S)
S
Estrogen inhibits bladder overactivity in rats with cyclophosphamide
BMS
Unleashing the potential of traditional Chinese medicine a computational approach to discovering drug targets utilizing the CSLN and molecular dynamics PMID 40317435
c
Diethyl phosphate
Effects of fluphenazine enanthate and fluphenazine decanoate on discriminated avoidance response and water drinking behavior in rats PMID 116283
Budoprutug 2720478
The LINC00319 binding to STAT3 promotes the cell proliferation, migration, invasion and EMT process in oral squamous cell carcinoma PMID 39366629
PLAGL2 promotes epithelial
XIE62
Rbm14
Framycetin sulfate 4146
NSC 625987 141992
XAP 044
X77 2455518
Chemical Biology, Molecular Mechanism and Clinical Perspective of γ
3
ALDH1A3
SDP116
J
AMSC
SR
The antiproliferative effect of acridone alkaloids on several cancer cell lines PMID 10217715
LY2775240 1628160
Synthesis, chiral resolution, and determination of novel furan lignan derivatives with potent anti
m6A methylation is required for dihydroartemisinin to alleviate liver fibrosis by inducing ferroptosis in hepatic stellate cells PMID 35248719
CRBN ligand
(9R)
Disulfiram alleviates epithelial barrier disruption in ozone
2
MAT2A
Mutation in Eftud2 causes craniofacial defects in mice via mis
Effects of E
(Z
hsa
APL180 388566
Comparative evaluation of 68Ga
VU0531245 (VU245)
Immune cell migration
CRBN ligand
Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy Current development and future perspectives PMID 35151222
2',3'
STING antagonist
NADH：泛醌氧化还原酶复合物装配因子 4（NDUFAF4）基因
(S)
Memory
Boc
1
UCM
A6770 1331754
Z
(+)
TLR4/NF
EGFR marks a subpopulation of dermal mesenchymal cells highly expressing IGF1 which enhances hair follicle regeneration PMID 37165726
PF
Holomycin, a dithiolopyrrolone compound produced by Streptomyces clavuligerus PMID 24323287
Anticancer agent 285 2878446
Amelioration of non
Litchi procyanidins inhibit colon cancer proliferation and metastasis by triggering gut
Roles of carbonic anhydrase 8 in neuronal cells and zebrafish PMID 24794067
The design, synthesis, and evaluation of organic dithienopyrrole
Desethyl chloroquine
Gaseous 3
Glutaryl coenzyme A lithium 103192
DBCO
Zeteletinib 2216753
[Tyr8,Nle11] Substance P 71890
Synthesis and evaluation of an (125)I
1
LDLRAD3 蛋白, Human (HEK293, hFc)
Gamma
Novel piperazine
Fmoc
Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors PMID 28094179
Rosiglitazone ameliorated airway inflammation induced by cigarette smoke via inhibiting the M1 macrophage polarization by activating PPARγ and RXRα PMID 34182323
PROTAC RET Degrader 1 2760847
1,2,4
SFRS8 Regulates Memory by Modulating RNA Splicing of Synaptic Genes PMID 40419750
Rab6a
Vcan
Factors affecting the amount and the mode of merocyanine 540 binding to the membrane of human erythrocytes. A comparison with the binding to leukemia cells PMID 7756353
Ifenprodil for prolonged spinal blockades of motor function and nociception in rats PMID 26922539
Revealing inhibition difference between PFI
Imidazole
SYF2 Human Pre
The analgesic effect profile of FR122047, a selective cyclooxygenase
Vitamin B6 is governed by the local compartmentalization of metabolic enzymes during growth PMID 37682999
c
VDAC1 Oligomerization
Bdnf Rat Pre
LIFR 蛋白, Canine (HEK293, His)
Periplocin Targets HDAC10 to Inhibit NF
Denosumab a review of its use in the treatment of postmenopausal osteoporosis PMID 21174488
Sodium salicylate ameliorates exercise
Cynaroside inhibits Leishmania donovani UDP
Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma PMID 41882358
HDAC5 抗体 (YA6590)（HDAC5 Antibody (YA6590)）
Biphenyls from Berberis koreana PMID 19813743
Britannin stabilizes T cell activity and inhibits proliferation and angiogenesis by targeting PD
Epha8
2
Discovery and development of thiazolidine
IL22
11β
Analgesic and potentiated photothermal therapy with ropivacaine
Effects of clenbuterol and antidepressant drugs on beta adrenergic receptor/N
LACC1 Human Pre
Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice PMID 38059822
Recent Advances with KDM4 Inhibitors and Potential Applications PMID 35838529
Cholecystokinin
The Toll
SFXN3 Human Pre
Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist PMID 24900329
LILRB2 Human Pre
Structural insights into the activation and inhibition of CXC chemokine receptor 3 PMID 38177682
含核糖核蛋白的 SAP 结构域（SARNP）基因
Dnase1
半胱天冬酶 12 (基因/假基因)（CASP12）基因
Substance P(1
Inhibition of insulin degrading enzyme suppresses osteoclast hyperactivity via enhancing Nrf2
A new immunomodulator, FR
Selenite as a dual apoptotic and ferroptotic agent synergizes with EGFR and KRAS inhibitors with epigenetic interference PMID 36864513
Lomefloxacin hydrochloride 98079
Discovery of novel inhibitors of human phosphoglycerate dehydrogenase by activity
HIV
Leflunomide impurity 2 455
KY216 2804026
Ginseng and Platycodon grandiflorum ameliorated pulmonary fibrosis and inflammation targeting TLR4
Anserine (beta
N
PIP2
Taraxasterone 6786
Wnt pathway inhibitor 4 663214
BMH
Guanylate
Design and synthesis novel di
17β
UCT943 1450666
2’,3’,5’
Potassium bromide, 99% 7758
leukemia cancer
2’
Pyridinium bisretinoid A2E
CD302/CLEC13A 蛋白, Mouse (HEK293, Fc)
Prallethrin 23031
KHK2805 (RA15
F1
Catharine
MicroRNA
Suppression of TRIM72
Met95
CXCR4 inhibition with AMD3100 attenuates amphetamine induced locomotor activity in adolescent Long Evans male rats PMID 33647040
SKF
TBCA 934358
8
Plevitrexed 153537
Suppression of TRPV4 channels ameliorates anti
神经元 1（NEUROG1）基因
Ferroptosis inducer
BMS986126
BMS
神经元中的蛋白激酶 C 和酪蛋白激酶底物 2（PACSIN2）基因
Astragalus polysaccharides exerts immunomodulatory effects via TLR4
HCLS1 蛋白, Human (HEK293, His)
Sensitivity of malignant rhabdoid tumor cell lines to PD 0332991 is inversely correlated with p16 expression PMID 21871868
Downregulation of lncRNA AFAP1
Firivumab 1443004
SHP2
Unraveling the molecular interaction of Larotrectinib with calf thymus DNA A comprehensive study using multi
(S,R,S)
Tatsiensine
Davunetide (Standard)
CI983
DBCO
W123 1345982
Cefadroxil hydrate 66592
Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor PMID 33733758
Apoatropine hydrochloride
Andrographolide
Antitumor Effect of Periplocin in TRAIL
Glycochenodeoxycholic acid
(±)
COB
Peficitinib halts acute kidney injury via JAK/STAT3 and growth factors immunomodulation PMID 39349115
Sodium
MN714
LAM561
STAT6 degrader
Methyl p
LY 345899 10538
EN1441
INS
2,5
Chk2
Distrontium renelate
DMT
HUJ591
STS557
Segregation of endoderm and mesoderm germ layer identities in the diploblast Nematostella vectensis PMID 40858588
hepatocytes
TLX591
PF 477736
Chk1
Sepsis induces non
FL 118
camptothecin analogue
Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off
BT
PF00477736
monkey
Karrikinolide
A2780
Rapid oligonucleotide
steatosis
The NK
DRGs
DEAH 盒解旋酶 40（DHX40）基因
Balicatib 354813
Mitigation of Tumor
The protective role of microRNA
Oxaliplatin and [Pt(R,R
Cremophor EL
Enhancing hyaluronidase enzyme activity Insights from advancement in bovine and ovine testicular hyaluronidase purification PMID 38330521
LIFR 蛋白, Human (HEK293, hFc
PGK1 succinylation modulates epileptic seizures and the blood
Keap1
Bisphenol A bis(3
Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor PMID 23947773
Tetradecyl palmitate (Myristyl palmitate)
Glycopyrrolate impurity 3
Inosine
TMRM 115532
含锚蛋白重复和 SOCS 盒 1（ASB1）基因
ARP
XAP 044
Polydatin induces apoptosis and autophagy via STAT3 signaling in human osteosarcoma MG
3
钙粘素 4（CDH4）基因
MCE
Synthesis and anti
STING signaling modulation by COPII cargo recognition PMID 41887218
In vitro antileishmanial activity of three saponins isolated from ivy, alpha
Relative distribution of Gb3 isoforms/analogs in NOD/SCID/Fabry mice tissues determined by tandem mass spectrometry PMID 27523577
1
Small
Opposing effects of CTLA4
MCE
Geleganidines A
Design, synthesis and biological evaluation of novel 1H
D
3
类粘蛋白 1（ORM1）基因
A Comprehensive Review of Zavegepant as Abortive Treatment for Migraine PMID 35774914
Comparative transcriptome analysis reveals key genes and signaling pathways mediated by salicylic acid in potato PMID 40691758
PBX
CP
CircPVT1 contributes to chemotherapy resistance of lung adenocarcinoma through miR
BCPA 547731
The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long
Palmatine attenuates hepatocyte injury by promoting autophagy via the AMPK/mTOR pathway after alcoholic liver disease PMID 35976121
F3 peptide
Entadamide
CRBN ligand
Topical cream
Vamp2
Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis PMID 11353624
VEGFR
1,2,3,4
GSK5852 1331942
1
Heparan sulfate proteoglycan is a mechanosensor on endothelial cells PMID 14563712
7(S),10(S)
1
CRBN ligand
IZS
Proform
Dnm1 Rat Pre
Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS
Fluorescent Heterocyclic Compound
Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one
MCE
Nicotinamide adenine dinucleotide phosphate alleviates intestinal ischemia/reperfusion injury via Nrf2/HO
Fmoc
CHF 4227 free base 444643
LncRNA LINC00641 Sponges miR
The MEK5/ERK5 pathway promotes the activation of the Hedgehog/GLI signaling in melanoma cells PMID 39998753
Curcumin suppresses tumorigenesis by ferroptosis in breast cancer PMID 35041678
Mpo Mouse Pre
MRTX
Preliminary in Vitro Assessment of the Potential of EST64454, a Sigma
The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo PMID 27027242
Hit 14 440338
79096
Acute glucose
DL
Styrylphenylphthalimides as Novel Transrepression
Cell division cycle associated 8 A novel diagnostic and prognostic biomarker for hepatocellular carcinoma PMID 34741389
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