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BAY
4
Dolichos Biflorus Agglutinin (Biotinylated) (DBA，Biotinylated)
Potent pseudosubstrate
(2S,4R)
Snai2
Flavanone and 2'
Mevalonic acid lithium salt 2618458
CIRBP is a novel oncogene in human bladder cancer inducing expression of HIF
B10
URAT1 inhibitor 8 1632005
Biotin Enhances Testosterone Production in Mice and Their Testis
Structure determination and comparison of BM567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition PMID 11327579
Design, synthesis and preliminary antiproliferative activity studies of new diheteroaryl thioether derivatives PMID 28838695
RG2833 1215493
脊髓损伤 (Spinal Cord Injury)
Exploring the combined therapeutic efficacy of bexarotene and icariin in type 2 diabetic rats PMID 39024515
N
Identification of anti
New substances of Equisetum hyemale L. extracts and their in vivo antitumoral effect against oral squamous cell carcinoma PMID 36535330
Effects of local structural transformation of lipid
利多卡因 d<sub>10</sub>
Igf2bp1
PRMT5
Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)
NESS 0327 494844
High
PNU
WAS
SUN1 Human Pre
Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium
UvsY protein of bacteriophage T4 is an accessory protein for in vitro catalysis of strand exchange PMID 2522995
2,5
Establishing a nonlethal and efficient mouse model of male gonadotoxicity by intraperitoneal busulfan injection PMID 31187778
Discovery of GS
4
Adenosine 5'
Diquinoxalino[2,3
ALCAM/CD166 蛋白, Rat (HEK293, His)
Paics Rat Pre
MATR3 Human Pre
MCE
9
硬化性 bHLH 转录因子（SCX）基因
FAM20C Modulates Neuronal Differentiation in Hypoxic
Il36rn Rat Pre
MuRF1
N
Secondary anchor targeted cell release PMID 26010879
Subtilisin from Bacillus amyloliquefaciens induces apoptosis in breast cancer cells through ubiquitin
CID 16020046 834903
Clec9a Rat Pre
BMS
Protein kinase Calpha contains two activator binding sites that bind phorbol esters and diacylglycerols with opposite affinities PMID 8617724
Chicken muscle antibody array reveals the regulations of LDHA on myoblast differentiation through energy metabolism PMID 37890747
[Therapeutic effect and mechanism of carboxyamidotriazole on the pulmonary fibrosis of mice induced by bleomycin] PMID 29534391
(1E)
1
Indoxyl sulfate, a uremic toxin, is biotransformed from indoxyl
碱性磷酸酶，生殖细胞（ALPG）基因
Role of Growth Differentiation Factor 9 and Bone Morphogenetic Protein 15 in Ovarian Function and Their Importance in Mammalian Female Fertility
MCE
Roflumilast n
Creb3 Rat Pre
BSCL2 脂滴生物发生相关，seipin（BSCL2）基因
Suppression of AKT anti
Wound healing of nanofiber comprising Polygalacturonic/Hyaluronic acid embedded silver nanoparticles In
LY75 Human Pre
PF
Indole
Phase I, Randomized, Placebo
LQB
Autoimmune myocarditis is not associated with left ventricular systolic dysfunction PMID 31125424
Effects of the bcr/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro PMID 10656455
Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthase PMID 26283693
PUS10 Human Pre
Antimicrobial peptide melimine coating for titanium and its in vivo antibacterial activity in rodent subcutaneous infection models PMID 26871890
Cdh3
Targeting the receptor tyrosine kinase RET in combination with aromatase inhibitors in ER positive breast cancer xenografts PMID 27602955
Efflux inhibitor
MCE
(
DNA2 inhibitor C5 35973
CRBN ligand
In vitro antiplatelet profile of FR171113, a novel non
Tempol prevents isoprenaline
Dyrk1A
Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA
PNU
p38alpha
Synthesis, antimicrobial, antiquorum
LTB4 antagonist 1 2929239
Modulation of chimeric antigen receptor surface expression by a small molecule switch PMID 31269942
Dok7
GW 5074 (Standard)
KU
BIBF1120
Nintedanib and ranibizumab attenuates pathological neovascularization in a rat model of oxygen induced retinopathy PMID 39952427
Protonstatin
Sodium diphenylamine
Bruceantinol 53729
Synthesis, antiproliferative and pro
Lumateperone
Treatment of trichomoniasis in the female. A comparison of metronidazole and nimorazole PMID 1098732
GNE0877 1374828
Clasps are CLIP
Stabilizing mutations and calcium
3,5
BAY8400
Chemosensitization of cancer cells by KU
IL17RD
U
Inhibition of multidrug resistance by adamantylgb3, a globotriaosylceramide analog PMID 18003606
H3K9me2
TW
PD 173955 analog 1 185039
Tnfrsf14 Mouse Pre
Significance of timing of angiotensin AT1 receptor blockade in rats with myocardial infarction
6
Thieno[2,3
PF
H3K27me2
Heme
Betulinic glycine amide
DZ
连环蛋白 1 的散乱结合拮抗因子（DACT1）基因
ACES
Identification of the first small
Rnf40
Cnn1
Dusp4 Mouse Pre
Fully synthetic nanofibrillar hydrogel for the growth and enzyme
Tri
Obtusichromoneside C 2414481
6
cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC
Therapeutic effects of Iranian herbal extracts against Trichomonas vaginalis PMID 28755655
Endogenous insensitivity to the Orco agonist VUAA1 reveals novel olfactory receptor complex properties in the specialist fly Mayetiola destructor PMID 29472565
Cappariloside A 229483
Cytotoxic principles from the formosan milkweed, Asclepias curassavica PMID 16252914
Adamantyl glycosphingolipids provide a new approach to the selective regulation of cellular glycosphingolipid metabolism PMID 21518770
The role of the helper lipid dioleoylphosphatidylethanolamine (DOPE) for DNA transfection cooperating with a cationic lipid bearing ethylenediamine PMID 23092705
Chemical Constituents from Campylotropis hirtella PMID 27220079
Packaged release and targeted delivery of cytokines by migrasomes in circulation PMID 39648224
Cyclo(GRGDSPA) 128857
STING agonist
Laminins in osteogenic differentiation and pluripotency maintenance PMID 32473527
Farnesoid X receptor regulates PI3K/AKT/mTOR signaling pathway, lipid metabolism, and immune response in hybrid grouper PMID 36210393
NECTIN2 Human Pre
The GABAergic pathway from anterior cingulate cortex to lateral hypothalamus area regulates irritable bowel syndrome in mice and its underlying mechanism PMID 38877776
Cefamandole, a cephalosporin antibiotic with an unusually wide spectrum of activity PMID 15828189
SB 243213 200940
Low
Potential treatment methods targeting 2019
ATF4 agonist
成纤维细胞生长因子受体 2（Fgfr2）基因
Effects of carboxymethylcellulose and hydroxypropylmethylcellulose on the differentiation and activity of osteoclasts and osteoblasts PMID 20665677
Serine/Threonine Kinase (STK) 33 promotes the proliferation and metastasis of human esophageal squamous cell carcinoma via inflammation
PF04171327
Capillary electrophoresis studies on the aggregation process of beta
GFRA2 Human Pre
Optical isomers of 2
Metabolomics Analysis of the Prefrontal Cortex in a Rat Chronic Unpredictable Mild Stress Model of Depression PMID 35370823
Historical insights into cytokines PMID 17972343
G 蛋白亚基β2（GNB2）基因
TACI 抗体 (YA3512)(PBS only)（TACI Antibody (YA3512)(PBS only)）
Nrg3 Mouse Pre
Rapid unleashing of macrophage efferocytic capacity via transcriptional pause release PMID 38480883
(Ethyldisulfanyl)ethane
HY
The implementation of high fermentative 2,3
Heptylbenzene
Biological properties of potent inhibitors of class I phosphatidylinositide 3
Adenosine inhibits activation
DnaJ 热休克蛋白家族 (Hsp40) 成员 C2（DNAJC2）基因
Anti
Enhancement and inhibition of mutation by o
Vicia villosa lectin
The synthetic diazonamide DZ
Identification of 2
Synthesis and structure
Pim
Indocarbazostatin and indocarbazostatin B, novel inhibitors of NGF
H
Synthesis and evaluation of new potential anti
(3
(3R)
Carbonic anhydrase inhibitor 3 2758231
MK
Homocholic acid
IC
Atiprimod dimaleate 183063
N
CEP126
Convergent evolution of a 2
GNMT 蛋白, Human (His)
(
Kijanimicin 78798
50862
RG108 48208
Methyl 6
Study on chemical modification and analgesic activity of N
Third
Hybrids of 3
Co(AIP)(BPY)
COX
Sideromycin 7
Human haptoglobin, mixed type (人结合珠蛋白, 混合型)
ATSM
PSMA
Effect of minoxidil sulfate and pinacidil on single potassium channel current in cultured human outer root sheath cells and dermal papilla cells PMID 7999667
Tumor microenvironment
MCE
Discovery of a novel Kv7 channel opener as a treatment for epilepsy PMID 25987375
IACS
(+)
Synthesis and evaluation of the NSCLC anti
HSD17B13
In vitro and in vivo immunopharmacological profile of Sch 40120 PMID 8450179
对接蛋白 7（DOK7）基因
Antiviral and lung protective activity of a novel respiratory syncytial virus fusion inhibitor in a mouse model PMID 21148224
丝氨酸棕榈酰转移酶长链碱基亚基 2（SPTLC2）基因
Assessment of bimodal laser photodynamic therapy at wavelenths of 410 nm and 653 nm for oral precancerous lesions An in vitro and in vivo study PMID 40127707
Epcoritamab induces potent anti
LDLR 蛋白, Human (HEK293, Avi
N
4
Anti
8354
VU0661013
Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period PMID 19458106
Structure, function and amyloidogenic propensity of apolipoprotein A
MCE
ML085
LCP
p110α
Gnetucleistol C
MRPS18B Human Pre
Discovery of Atractylenolide Derivatives as Novel LSD1 Inhibitors for the Treatment of Alzheimer's Disease PMID 40470974
Effects of Estradiol and Progesterone
N
Messenger RNA regulation to translate or to degrade PMID 18256698
Imatinib
Checkpoint kinase inhibitors SAR and radioprotective properties of a series of 2
Cell cycle arrest and antitumor activity of pironetin and its derivatives PMID 9563645
Type I collagen is overexpressed in medulloblastoma as a component of tumor microenvironment PMID 17653508
Prostaglandin F2α methyl ester (PGF2α methyl ester)
Delphinidin
bacterial transcription initiation complex
Creatine kinase MM TaqI and methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms influence exercise
IL4R
The choleretic role of TUDCA exacerbates ANIT
Qushi Huayu decoction attenuated hepatic lipid accumulation via JAK2/STAT3/CPT
mGlu2/3 receptor antagonism A mechanism to induce rapid antidepressant effects without ketamine
Abarelix and other gonadotrophin
Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR PMID 29541370
Preclinical and First
Aurones and derivatives as promising New Delhi metallo
(6S)
PTPN7 Human Pre
Malaria blood stage infection suppresses liver stage infection via host
Lamp2
A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage PMID 33984334
L
SB
GNE
(S)
New strong fibrates with piperidine moiety PMID 11145154
CB30900 145788
Adaphostin 241127
Identification of efficient pentapeptide substrates for the tyrosine kinase pp60c
IL
Photoliberating inositol
TY
Haloperidol impurity 12
Tau
Amaronol B 226561
INF7 185462
Carboxylesterase
OBSL1 Human Pre
Isobonducellin 610778
Activation and activity of glycosylated KLKs 3, 4 and 11 PMID 29975661
BTdCPU 1257423
(R)
Hydroxytyrosol 4
vacuolin
STING
Chemical Modulation of Protein O
1
抑制剂
Implication of lncRNA ZBED3
Dnmt3a
1
Mechanical force modulates macrophage proliferation via Piezo1
Bemcentinib enhances sensitivity to estrogen receptor inhibitors in breast cancer cells PMID 39900236
ID1 inhibits foot
Ketoprofen L
(4S)
Potential cytotoxic and anti
KUS121, a valosin
Targeted up
A modified natural small molecule inhibits triple
AZ
Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM
Aeruginosin B
The hydrolysis of phosphatidylinositol monolayers at an air/water interface by the calcium
INA03, a potent transferrin
3’,5’
Cimiside E 154822
Bistacrine derivatives as new potent antimalarials PMID 27316542
Conformational Role of Methyl in the Potency of Cyclohexane
Genotoxicity of tryptophol in a battery of short
Antitumor and anti
PSMA 蛋白, Mouse (Biotinylated, HEK293, His)
Endoglycosidase F3 (D165A mutant) (EndoF3 D165A)
Keap1 抗体 (YA324)(PBS only)（Keap1 Antibody (YA324)(PBS only)）
BH3 mimetic Obatoclax (GX15
FGF
HA/Hemagglutinin 蛋白, H1N1 (BAK23277, HEK293, His)
Kibdelin B 103528
Design, Synthesis, and Biological Evaluation of Lysine
1,1,3,3
Hexacosanoic acid methyl ester
Polysaccharides from Polygonatum cyrtonema Hua prevent post
β
PD 128907 hydrochloride 112960
Murine monocyte chemoattractant protein (MCP)
NFAT2 Induces Tumor Cell Proliferation and Metastasis by Acting as a Transcriptional Co
Acepromazine
Development of curcumin
Rad23B 抗体 (YA4094)（Rad23B Antibody (YA4094)）
Fn1 Mouse Pre
CM010 692269
Epha3
CHES
Eif3d
HEXB Human Pre
Potential Combination Drug Therapy to Prevent Redox Stress and Mitophagy Dysregulation in Retinal Müller Cells under High Glucose Conditions Implications for Diabetic Retinopathy PMID 34940029
Control of signaling
5
CTAG2 Human Pre
Picroside II Protects SH
Synthesis and biological evaluation of the 1,5
AF710B, a Novel M1/σ1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer’s Disease PMID 26606130
Numb
miR
Aldose reductase inhibition with imirestat
Inhibitory effect of HSR
Expression of bovine beta
Protein kinase affinity probe 1 2098621
B3galt5 Mouse Pre
microRNA
Lacticaseibacillus rhamnosus Fmb14 prevents purine induced hyperuricemia and alleviate renal fibrosis through gut
SAE1 Human Pre
Targeting CXCR4 potentiates anti
A Novel Small Molecule ITK Inhibitor Suppresses Th2/Th17 Differentiation and Attenuates Airway Inflammation in a Mouse Model of HDM
SAS
Aerva lanata extract
Inidascamine 903884
An analysis of the expression and function of myeloid differentiation factor 88 in human osteosarcoma PMID 30250559
Synthesis of 6
Zingiberenoside B
Guanine
(+)
Text Mining and Drug Discovery Analysis A Comprehensive Approach to Investigate Diabetes
Circulatory effects and pharmacology of clevidipine, a novel ultra short acting and vascular selective calcium antagonist, in hypertensive humans PMID 10445679
2
Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin
N
MTX115325 2750895
CDK2
Gomisin N 69176
Tumor microenvironment
MCE
CHI3L1 蛋白, Mouse (HEK293, His)
Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3 PMID 29626115
MCE
CaMK1a/CAMK1
Crebanine ameliorates ischemia
MC Receptor
Conversion of antigen
C5aR1 inhibition reprograms tumor associated macrophages and reverses PARP inhibitor resistance in breast cancer PMID 38802355
CD69 Targeting Enhances Anti
Teriflunomide 163451
Cd46 Mouse Pre
SM 10888
Homoallyl bromide
FGL1
FB2001
MCE
DL
Subclinical Herpes Simplex Virus Type 1 Infections Provide Site
cis
MCE
MCE
5
Methyl 2
Ipflufenoquin 1314008
Fenbufen
2
Fmoc
p38
PF
DNA
Desoxycorticosterone pivalate 808
5
A neuropathological analysis of experimental autoimmune encephalomyelitis with predominant brain stem and cerebellar involvement and differences between active and passive induction PMID 10963365
BCLAF1 Human Pre
Discovery of Selective and Potent ATR Degrader for Exploration its Kinase
BMS
Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system PMID 23850985
Spirapril prevents left ventricular hypertrophy, decreases myocardial damage and promotes angiogenesis in spontaneously hypertensive rats PMID 7681495
Low tumor glutathione level as a sensitivity marker for glutamate
(2’,3’,5’
Oxygen vacancy
CeKDM7A
AM
(S)
Sap130
Design and Synthesis of Brain Penetrant Trypanocidal N
MCE
Aloc
Benzarone 1477
2
Design and synthesis of novel 1,2,3
2'
hsa
6
D
(S)
(R)
Increasing O
Suppression of LSD1 enhances the cytotoxic and apoptotic effects of regorafenib in hepatocellular carcinoma cells PMID 30929918
Aminopropyltrimethoxysilane 13822
CVT
Ligand
hCAIX
Decrease of NAD+ Inhibits the Apoptosis of OLP T Cells via Inducing Mitochondrial Fission PMID 39871961
BAY
1,6
WDR5
Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists PMID 31098001
Pim
N6
MCE
KLKKTETQ 1054611
Differential Mechanisms of Cell Death Induced by HDAC Inhibitor SAHA and MDM2 Inhibitor RG7388 in MCF
Metabolic disruption exacerbates intestinal damage during sleep deprivation by abolishing HIF1α
Linear polyubiquitylation of Gli protein regulates its protein stability and facilitates tumor growth in colorectal cancer PMID 39164252
BAY 8400
(S)
α
Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination PMID 21122808
Irradiation accelerates SARS
Soluble phenylpropanoids are involved in the defense response of Arabidopsis against Verticillium longisporum PMID 24483326
Z
3
Herpetin 911052
Influence of the anti
Atosiban 90779
α
tert
M1145 1172089
IL
Revisiting IL
Erdafitinib promotes ferroptosis in human uveal melanoma by inducing ferritinophagy and lysosome biogenesis via modulating the FGFR1/mTORC1/TFEB signaling axis PMID 38971541
Investigation of safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of a long
LAMP2
BAY
Folate derived from cecal bacterial fermentation does not increase liver folate stores in 28
Heterogeneous nuclear RNA double
瑞格非尼
CRBN ligand
(E)
瑞格菲尼
Structural analysis of lipopolysaccharides from Gram
MEK
Adenosine
瑞戈非尼
DMT
CTLA
CRBN ligand
ZY1
Neflamapimod (Standard)
Similarity searching for anticandidal agents employing a repurposing approach PMID 38095132
DMT
CTLA
Guanine deaminase, Human
DRAM1 Human Pre
PROTAC Sirt2 Degrader
Prostaglandin E2 Ethanolamide 194935
Prohibitin 1 regulates mtDNA release and downstream inflammatory responses PMID 36245295
Fc 受体样 1（FCRL1）基因
Tada3 Rat Pre
[1,1'
The discovery of the potent aurora inhibitor MK
N
Erythrinin G 1616592
Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide
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